Modify INI File Settings
The INI Files stored on Skyrim installation directory contains various settings and required information. You need to modify them to fix Skyrim crash.
Open My Computer.
Open this directory: C:\Program Files\Steam\SteamApps\Common\Skyrim\Skyrim
Right click the file called SkyrimPrefs.ini and select Copy.
Paste it to your desktop.
Now, in the original directory, right click SkyrimPrefs.ini file and select Open With | Notepad.
Click Edit | Find.
In the Find What box, type bMouseAcceleration and click Find Next button.
Change its value to 0. (Assuming that the default value would be 1)
Click File | Save.
here are some procedures given regarding this issue and it worked for me:
http://www.backspacetab.com/skyrim-crash/