Army of Two has some NPCs run out you guns blazing while screaming "HERE GOES NOTHING YOU LITTLE *****! AAAAAAAAAAAAAHHHHHHHHHHHHHHHH!" There are other little gems in that game, including: "Holy shit, he's not dead!" and "What the fuck, THERE HE IS!"
My favorite lines are from resident jackass Phillip Clyde:
"I'm gonna kill you both, slice you open, and go to an aerobics class using your intestines as leg warmers!"
"I'm gonna kill you both, drain out all your blood, take out your bones, put your body in a big chair with some elves and reindeer, and sit on your lap and tell you all the cool shit I want for Christmas."