Personally, until one of the established in-universe rules is broken repeatedly, or multiple rules broken.
Say, for example, that in the game people have an innitiate magic ability of flight. Groovy, I can dig that.
But then, to be faced with a loss or though choice that could have been resolved/sidestepped for the better by flying, but for an unexplained reason being unable to, I can't take. Because it has already been established that people can fly. Likewise, if you establish that dead people can be resurrected, there ought to be no dead party member that you can't resurrect without adequate reason.
My suspension of disbelief is pretty great when it comes down to the rules beneath a realm. Flying people, disregarding Einstein and Newton while in space, dimension hopping aliens, gods who respond to prayers etc. Doesn't matter, as long as it is consistent.