Mage Knight is a beastly game. It takes the basic idea of a deck building game and expands it into a huge and involved and brutally hard fantasy game. You can do co-op scenarios or you can kill each other. In my experience, it's best with 3 players, and a game usually takes about 4 hours, so it might not be great for a social gathering, but it's worth trying.
Mansions of Madness is probably the best of the Lovecraft genre of board games. The storytelling element is in the forefront, and gameplay is much more straightforward than Arkham Horror.
Last Night On Earth is solid, but if you can find it, Invasion from Outer Space is better. It's essentially the same game with a funner theme and more interesting scenarios (there's an unstoppable beast that is only weak to the smell of cabbage and a dancing bear that get extra bonuses when riding a unicycle). The same company also makes Touch of Evil, which is about an 18th century town fighting off folktale horrors like werewolves and the headless horseman.
Eclipse is a fun one, all about space exploration and combat with tons of flexibility about how you want to build and equip your fleet. Alien Frontiers is space themed but is essentially a worker placement game with tons of dice rolling (I love dice rolling), and it is probably my favorite game.
If you're trying to get one big group game, Battlestar Galactica is good, but avoid the expansions. They ruin everything.
If you like Resistance, Ultimate Werewolf takes it to the next level with tons of extra roles outside the basic werewolf/villager dichotomy and a much stronger element of bluffing and reading people as opposed to Resistance's more logic-based reasoning.
Sentinels of the Multiverse is a fun superhero themed card game with a few expansions available now, which leads to a ton of replay value between the 20 or so heroes, 10 villains, and 10 venues to have the fight. Between the expansions and the base set, you could get two or three games of this going simultaneously.
Descent and its more family friendly cousin Mice and Mystics offer a sort of campaign with prepared storylines and chapters and level ups and DMs and stuff if your group is up for a long term project. I like Mice and Mystics more just for how fun the theme is.