That line is the trigger to my best friend's punch-me-in-the-face reflex. I stay away from him when he's playing BioShock for that reason. Anywaaaaaay...DonMartin said:
The obvious one would be "The Cake is a lie." But honestly I don't see why so many people love that line, especially since it's not even spoken dialogue or anything. I will admit that I'll remember that line for a long time longer than most other things from Portal, but that's because of how often people say it.
The line that I'll always remember because it's awesome was this gem from the first time you talk about sex with Alistair in Dragon Age: Origins. "Have you... ever... stuck your tongue to a lamppost in winter...?" Not exactly the best line but I think anyone who actually had that conversation in-game would agree it's amusing.
