For one thing, the "Bookmark" button on the corner of each thread will explode in flames. The comment section of Yahtzee's final video will have all its comments replaced by gibberish, the text on the rest of the site will be converted to a combination binary and Chinese, and the images of all the people from the other Escapists series will be scribbled with Joker faces.
Honestly, I think it'll be business as usual.