Super Mario and Dynasty Warriors - Mario's taken on armies of underlings over the years, but it's always been one stomped shell at a time. Lets see him fight 1000 goombas at once and see how tame he stays.
Half-Life and Final Fantasy - How do you take what some consider to be one of the smartest science fiction games out there and successfully merge it with a time-honored, yet somewhat hackneyed JRPG franchise? Like this: HEV Suit with materia slots, GLaDOS as the sassy bad who eventually warms up to your party and joins you, DOG as a GF, G-Man joins your party and has amazing stats, but leaves in the middle of the fight with the big bad, and finally, GASP! Barney kills Alyx with Gordon's crowbar Sephiroth style! "I think you left this back at Black Mesa, fu fu fu..." O:
Grand Theft Auto and Pokemon - A Rare Candy smuggling ring. A Jinx caught in a vicious cycle of prostitution and Potion abuse. A crime lord who fixes one-on-one Gym Leader duels for a living. Former "Pokemon Trainer" Red is going to learn that these are things you have to do to survive on the rough-and-tumble streets of Viridian City. It's nothing like Pallet Town, that's for sure. It's Grand Theft Pokemon.
NintenDogs and Time Crisis - At it's core, it's still a game about raising a puppy to maturity. This time, though, your goal is to train the puppy into a vicious member of a K9 Police Force with a taste for criminal flesh.
Super Mario and Halo - This one's for Luigi. Ever wonder what he does while Mario's off saving the Mushroom Kingdom? Here's a hint; Master Chief's SPARTAN armor isn't green just because it's aesthetically pleasing.