I'm gonna have to kick it old-school and cast my vote for Ranma 1/2. Come on, transforming into a random animal when hit by water? Priceless. And Shampoo is -still- the hottest girl in anime.
Or FLCL. The sheer awesome would be mind-blowing. And the guitars, pure win.
Or FLCL. The sheer awesome would be mind-blowing. And the guitars, pure win.