I think Lara Croft is one, excuse the word, "ballsy" main character. I know she's quite mainstream, and well know, and basically the arch type heroine now, but back when the first Tom Raider was developed, I think it was a bald move to go for a female main character in a media that was then dominated by adolescent boys.
Of course, you might argue that staring at the bottom of a well built woman (and positioning her to walls so the camera would allow a frontal view of... two pyramids) does sell to that demographic, but then you could've always gone for a sexy female sidekick for a male protagonist, which would have been easier to identify with in the target demographic.
So thumbs up for the original Lara Croft!