Actually no, I think if a character is well-written enough they won't make sense to simply gender swap. Shepard works because he or she is a slab and has no quirks or traits. RPG characters work because they don't say anything, rely on players for their input or speak entirely with text. A character that is based on gender alone is poorly written, but a well-written character is inseperable from what they are.
Also double the voice acting and Nolan North cannot sex change on demand.
Also double the voice acting and Nolan North cannot sex change on demand.