Considering nothing Double Fine has made since Psychonauts has made it to the PC (because of the publishers, if I recall. I remember reading that if Double Fine were able to decide for themselves what platforms their games released on, they would be on PC as well.) I really hope that if/when they make a Psychonauts 2 that it makes it over to PC. Honestly, it would be silly for it to NOT get ported to PC since most of the sales and attention Psychonauts has gotten as of late has been through Steam and other PC digital distribution platforms.
I'm totally fine with ports, as long as they're done well. If the keybinds are customizable, the graphics settings can be changed in depth, it's well-optimized with system requirements that aren't crazy, and it's not riddled with bugs, I consider it a successful port. Even better if it's open to modding, has a command console, and perhaps comes with an editor of some sort.