By play, did you mean you beat it? If so,VMK said:*Spoilers ahead (probably)*
First of all, death of Mordin and Thane in ME3. I just loved those guys.
Next:Shadow of Colossus. Not that I cried, but I felt some sort of crying feeling every time I killed the Colossi.
But the most tear-bringing moment for me is ending of Final Fantasy X. Six times I've completed it, six times I cried.
I played the game. Which scene are you talking about?deserteagleeye said:That one scene in Persona 4 and the ending. I wouldn't dare spoil it.
The scene with Nanako in the hospital. When she died. That was sooooo sad for me.