Most Annoying in-Game Enemy.

[Khazoth]

Snipers in Mirrors Edge, who seem to have auto aim. This is FRUSTRATING WHEN YOUR TRYING FOR THE PACIFIST ACHIEVEMENT.

Yao Guai and Deathclaws who follow the murphys law of "The bigger they are, the better they are at sneaking up on you." Often you don't know you're being attacked by one unless your health is rapidly dropping.

Back on World of Warcraft, anything that could heal. Damn it i'm a warrior, I lack the lasting power so STOP HEALING YOURSELF YOU CLOD. Sucks being arms when your not PvPing, and of course I am speaking of the World of Warcraft before it was canceled. A shame it was canceled too, they were just about to release that Expansion Pack, The Burning Crusade.

City of Heroes had this enemy group called Malta, who have an enemy called The Sapper, who saps your endurance... When you're out of endurance you can't attack. This wouldn't be as bad if Malta didn't have something called a Gunslinger which can mow you down. Oh and if you do Smashing or Lethal Damage? Your double fucked.

And finally? Attack Helicopters in Saints Row 2.. They have homing missles and are hard as fuck to avoid their lock on targeting.

 

[Padefe]

Ppakk the third - slow, high damage, too much health for a mini boss and is f****** ugly.

Those damn little annoying germs or aliens that is in dead space, jumps on you and eats your suit.

Pacman ghosts.

The last enemy on space invaders.

Super Bilstein - Star Gladiator.

Jakal Snipers - halo 3 legendary mode.

 

[Dazzaa]

in order of annoyace
krill in Gears of War

cliff racers in Morrowind

and mutants in Far Cry (honestly i'm surprised nobodies mentioned them yet, they see through walls or bushes, can leap at you from 10-15 metres away and kill with a single hit, and the game runs on a checkpoint system, so no quicksaves)

 

[IxionIndustries]

I really, REALLY hate the pixies from Fable. They fly around, and are only attackable when they summon enemies to attack you, or shoot spells at you. Sure, they go down pretty easy, but aiming at them with a bow or magic is really fucking hard.

 

[SweetWarmIce]

Polarity enemies in Too Human

 

[Joshimodo]

Morrowind's Cliff Racers or Halo 3's ridiculous shooting Stalkers (I can't remember their proper name).

 

[NeutralDrow]

Pretty much everything in <url=http://tvtropes.org/pmwiki/pmwiki.php/Main/GoddamnedBats?from=Main.GoddamnBats>these <url=http://tvtropes.org/pmwiki/pmwiki.php/Main/DemonicSpiders>two entries.

 

[Acid Armageddon]

Mirelurks from Fallout 3. You have to use VATS to shoot em in the face, and when they get close, they deal tons of damage real quick!

 

[ChosenLord]

I agree with the Pixies, those Cu*ts are brick to aim at,

I'm gonna add the entire dwarven faction in BFME2 - twice as much health and twice as much attack? talk about balance, the scales are in an infinite loop orbiting middle earth.

Maybe its me but i hate the dags <- (Bit irish there) .. Dogs in the first Resident Evil, maybe its because ever since watching American wear wolf when i was 10 i had a fear of canines, but they are such an arse to kill, same with them in COD4 too, i know you can get around them, but.... well you catch my drift.

 

[Valkyira]

The boss fights on Dead Rising... all of them.

The Dead Rising boss fights are so easy once you get the 2 mini chainsaws with the books. They last for ever and they kill any boss with 2-4 slices

 

[lordsandro]

The Trolls from Oblivion. These fuckers just don't die.

The big guy with the rocket launcher from Quake 2. The one that fucks you up when you are low on health.

Every single enemy from Silent Hill 3.(If you are not playing on easy) They will just !#$@ your %##.

 

[Crowser]

Choppers in CoD4 multilayer

"Oh my god I'm one away from my all time kill streak, just don't fuck it up. Just gottBAMABMBAMBAMBAMBAMBAMBAM *Dead*. *Watches kill cam*

"Seriously, through the fucking concrete WALL!?"

 

[Tharwen]

Anything with a poison attack after your last antidote has been used up.

(Poison is really hard to type quickly; I kept writing posino.)

 

[Azazcyh]

Those damn bats from ninja gaiden, they seem simple enough to kill but I can't hit the bastards.

Ether that or the flying fish, before you find out how your supposed to kill them.

 

[PurpleLeafRave]

The flying mechs in mechassault 2...
and the ones with the big blue fireball things, grrrr!

Snipers are annoying rainbow six vegas too, one shot kill.

 

[ganpondorodf]

Loopers in Skies of Arcadia. They have hardly any health, but a really high dodge %. Just when you're about to hit one with a massive never-miss move that has enough power to eradicate its health bar twenty times over, it runs. GEARRRGGGGGGH

Also I must agree with the folks earlier who mentioned the krill from Gears of War. Goddamn it I hate that section of the game; it's just a series of cheap-ass kills.

 

[Wafflestomper99]

The Final Boss from Dead Or Alive 4. Seth from SF4 is cheap, but not that cheap

 

[DoctorWhat]

Can't remember what they're called, but those exploding little things from Gears 1...

grrr... Died so many time 'cos of those little things...