Bob Paige in Deus Ex`s Helios ending "Helios - don`t leave me!" sort of resonated with me.
Similar with Gunther Hermann's end. While not much was said in the actual dialogu, reading the journals in the Knight's Templar castle shook me up. After having the only woman he could have loved killed by JC, he dedicated himself to ending Jc's life, only to be cast off by his employer as a mere puppet, afterwards.
I would have to ditto Andrew Ryan's demise. Absolutely disturbing as hell and equally pathetic.