Let's say any of the Marvel video games's continuity. I would say especially X-men Legends, its like:
"Ok, so you play as this girl who can generate lava and flame from rock, and she is from a lost roman colony in the middle of the amazon that was left untouched for two thousand years, only it might just be a collection of people brainwashed into believing that, nobody really knows.
You are recruited to help stop Magneto, who was a holocaust survivor, but is only in his forties because of a alien who de-aged him. Magneto's top lieutenants are a century old shape shifter, a pyromaniac, and a guy called the "blob" whose mutant power is being immobile when he wants. All three of which were assumed dead at some point or another, and Magneto himself has appeared to die a minimum of three times.
The X-men you help include (among others) Psylocke, a telepathic British woman in an Asian body, who wound up this way because of a dimension jumping nutcase with magic powers and six arms, Jean Grey, who has come back from the dead multiple times and was once replaced by a cosmic entity who nearly destroyed the universe, Forge, whose mutant power is essentially "To build anything required for the plot", Gambit, a thief who had himself brain damaged by one of the x-mens enemies because his powers were so strong he could have destroyed the planet..."
About this time I usually have to stop explaining because the person I'm talking to has walked away, shaking their heads.