I was just playing a while ago. New character (only lvl 6) and was facing two well-armed Raiders. I just had a 0.33%-repaired Hunting Rifle with a handful of ammo.
It took an agonizing number of shots to take down the first Raider, and he did a fair amount of damage to me before he finally went down. I had, I'd guess, about 4 hp left when I turned to the second Raider, who had full health, and was charging me with his Sawed-Off Shotgun.
The voice in the back of my head said, "So this is it? We're going to die." I realized I hadn't saved in far too long a time.
Lacking any Action Points, I quickly (and roughly) took aim at his head and hoped for the best, pulling the trigger. If I missed, not only would I be left with a single bullet, but the Raider had just finished his reload. It was now or never.
Almost instinctively, my thumb twitched upward at exactly the right time, because as I pushed "fire" it locked in perfectly. The Raider's head exploded with a satisfying one-hit mess.
The Wasteland was silent again, the Lone Wanderer standing there, haggard, over the mangled Raiders. All I had to say was this: "Fuck you."