Only been all the way through once, I supported Mr. House... and conceptually, he's right... but he's still kind of a dick. Very vindictive in his unwillingness to work with certain reasonable parties.
Mind you, the NCR isn't that much better, but they do have a greater concentration of reasonable people than any of the other choices.
I guess I'd rather use Yes Man to put the Followers of the Apocalypse in charge, if that were an option... but completing his quest lines has you doing rather dickish, power-mongering things as well.
As for Caesar's Legion... no, just no. Completely disgusting.