Well, speaking for myself I'd kind of like to meet up with the main force of the Brotherhood Of Steel at some point, we generally wind up dealing entirely with their offshoot factions, rogues, scouting parties and forward bases, etc... never with the main group, despite them apparently having a substantial prescence somewhere. They apparently have an endgame in mind, I don't see the whole "they scavenge and protect technology but then have no plans for it, or long term goals" as making much sense. The Commonwealth is another faction that I think could use some more exploration.
I think we've gotten to a point where Super Mutants should be pretty rare given their problems with reproduction, I think they have had too great a prescence for too long given the game lore.
I do not think they should develop the game's population too heavily, after all if there are people everywhere it's not going to seem very post-apocolyptic. This is the problem with building a working infrastructure and ecosystem in game, by the time you spell all that out it won't seem empty and desolate anymore. There are conceptual problems with some of the towns and such if you look at it purely from the perspective of in-game assets, but truthfully I find it better to just assume there are things going on that you don't see or have any real dealing with in the course of the game.
I'm also surprised to have to point out that when it comes to things like "Little Lamplight" they are dealing with post-apocolyptic stereotypes, if you've seen things like "Mad Max: Beyond Thunderdome" you should get the idea. There are all kinds of vicious child gueriellas throughout the second and third world, african warlords and muslims conditions kids to fight and kill as early as 8 or 9. We tend to shut this kind of thing out, even when we learn it intellectually because it's so contrary to the beliefs of western society and our practices, but that's how things are, and in a barbaric enviroment your going to see a lot of that. To me I never really had a problem with the basic idea of "Little Lamplight" having seen the source material, and being able to believe that armed kids could hold a defensible location, my problem was that they were obnoxious and protected by invincible plot armor to force you to jump through hoops in order to progress.... Little Lamplight is an example of exactly what Bethesda should NOT do in Fallout 4, but the idea of a settlement of children isn't itself the problem.
Of course I also suspect Bethesda is gently trolling it's userbase, I think Bethesda knows how the obnoxious "invinci-children" go over, but they have put them in other games like Skyrim, so I get the impression it's a joke of sorts on their part to have some little kid running around talking about kicking your arse to the point where you just want to punt them but can't. There is probably a developer that thinks it's hilarious. Some people look at the whole thing as a "child murder contreversy" and ask why people want to kill children... me personally, I tend to look at the developers for greating situations that make me want to kill the children since I have no impulse to do it other than running into them in some of these games.
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To be honest I am resistant to the idea of bringing Fallout to other parts of the world. I understand why people want this, and to see how there are survivors in their neck of the woods, but at the end of the day I feel that it's counterproductive to the idea of an apocolypse. Small pockets of people surviving in North America, in the US, which is the most powerful nation the world has ever seen, is supposed to be incredible in of itself. It's less incredible if you start building european survivor communities and similar things dotted all over the globe. "Everyone else is dead" is part of what makes the concept so grim.
To put things into perspective "Horseclans" is a series by Robert Adams which takes place after a nuclear war, but it's hard to really call it post-apocolyptic fiction, because it involves these huge populations of surviving people, with the nuclear war being mostly an excuse to populate the world with new, low-tech civilizations, intent on beating each other over the head, with the occasional spectre of old technology rising up to present a threat to our protaganists when then bad guys get it. It's more general "action-adventure" fiction. You have greco-romans, oceans full of pirates, european civilizations, mexican civilizations, north american civilizations, and pretty much everything else you could want, but at the end of the day it's no less populated or more apocolyptic than say "The Forgotten Realms" it just has psionics instead of magic, and a bunch of immortals acting as the major heroes and villains.
To that end I think it's probably best to just flat out say Tenpenny is a liar. You wonder how he pulled this off... well obviously, he didn't. If he had done that everyone would know it and be screaming it from the rooftops, and you wouldn't need to ask him. Conversely, if anyone had transoceanic travel it would change the entire world structure by it's very existance.
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For characters I'd like to see a more robust, and RPG-like character system, as opposed to the increasingly stripped down action-shooter direction they have been going in. To be honest I'd like to see them add more, and more specialized skills, combined with more skill selections for things you ccan know, but no abillity to ever max out all of the skills and become capable of doing everything. One of the big problems with Fallout 3 and New Vegas in my opinion was that I felt my choices in skills were kind of meaningless since I was going to pretty much know everything anyway and be maxed out even after increased level caps long before I depleted the content. The only time "choice" or having a "build" seemed to matter was the very beginning of the game.
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Oh and some better character art, to be honest ever since Morrowwind Bethesda seems to have gotten on this kick for freakishly ugly characters, you can get something that's passable if you fiddle with the sliders, but unless you have a lot of talent coming up with a character that is actually good looking (if you want one) is nearly impossible. Even when not shooting for a character who is pretty/handsome I'm usually not happy with how my character's face looks (not that it winds up mattering much, but I should be). What's more while the slider system adds a lot of "power" for character customization, in pretty much every game that uses it the character creator doesn't do a good job of representing how the character looks in-game in terms of relative proprotions. More than once in say Skyrim or Mass Effect (which isn't Bethesda's fault) I've made a face that looks good, started the game, and then noticed hideously protruding facial growths (like cheekbones sticking out 4" when viewed from a certain angle) when actually rendered in-game.
Seriously, some better character generation tools would be nice.
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Being able to choose differant "origins" of your character sort of like "Dragon Age: Origins" would be decent as well. I agree that being able to choose whether your a vault dweller, a tribal, a townsperson, etc... with slightly differant beginning set ups would be kind of cool.
Not sure how I feel about races other than humans being playable though. On some levels I've always felt that Ghouls are ideally adapted to the enviroment and have been surprised they haven't done better/risen to greater dominance. Playing a ghoul or whatever strikes me as simply making the game too easy. Any social barriers being easily overcome by high speech skills, or just opting to kill everyone, it makes any kind of predjudice being more than an occasional "you are a ghoul" acknowlegement being kind of pointless, there aren't any real balancing reasons why you wouldn't play one if you wanted to min-max the game.