Find an agent to throw your book at publishers. If you cannot, or your attempts at pitching to publishers isn't working, look for an editor.
A few things to remember:
1. The first five pages of your book should be catchy, exciting, and something that will draw in the viewer. This is especially true for the first page, itself. Everything in these pages needs to be as good-looking at you can get it.
2. Publishers don't want to read your entire book in one go, they want to read those first 5 pages and a synopsis. (You can get away with sending in up to an entire first chapter with some publishers.) If you send them a manuscript consisting of 1200 pages, you will be passed by.
3. Editors are vital. You may think your book is the bees knees, but believe me it is not. There may be stuff you need to add, or entire sections of your book that you may need to remove. Your book also may be a grammatical or spelling nightmare. Sometimes a publisher will send someone to read over and edit your book for you if it manages to get through the door, and sometimes they'll throw an editor at you even if you've already been through one just in case.
4. Try multiple publishers. Unless you have an agent, you will likely be passed up multiple times over the course of a few years. So sit tight and be a persistent little *****.
5. If a publisher finds you, read the fine print of a contract very carefully. This is also why an agent is important. Reserve your rights - don't readily hand your ideas, characters, and story to a random publisher. And don't agree if you'll only make something like 5% of the profits or no profits until 2,000 books are sold. There are TONS of publishing scams out there.
6. Be warned that with some publishers, the artist who does the cover for your book may make more than you.
Try Barnes & Noble. They're taking on starter authors if you agree to sign a 3 book contract.
As for independent self-publishing. It's expensive, a pain, and you don't make nearly as much in my opinion. You'll spend tons of money and time desperately trying to get to as many conventions as you can to sell your book and get your name out there.