It doesn't matter much what your starting skills are, but somethings turn out to be more useful than you'd think.
Short Blades are not a particularly good weapon, but the best of this kind turn out to be pretty easily acquired - you can get a daedric short blade for free when visiting Mournhold, if you defeat the attacker wielding it.
Personality doesn't seem like a game breaker, but if it's high enough then many brigands who would normally attack you won't.
Mysticism has a few spells that make the game a lot easier - Detect Life and Detect Magic in particular.
Short Blades are not a particularly good weapon, but the best of this kind turn out to be pretty easily acquired - you can get a daedric short blade for free when visiting Mournhold, if you defeat the attacker wielding it.
Personality doesn't seem like a game breaker, but if it's high enough then many brigands who would normally attack you won't.
Mysticism has a few spells that make the game a lot easier - Detect Life and Detect Magic in particular.