I love the 360 controller (honestly, you must have small hands to complain about this gen's size)
the original Xbox's original original brick (you know, the massive one that was like the Dreamcast) wasn't uncomfortable just too bloody big, but the fix was great and the 360 just honed it to perfection
the N64 controller was great too, even if the left side was more or less ignored (odd looking but once you figure out how to hold it haha)
the GameCube controller was all right, it was a bit odd (not as odd-looking as the N64 controller tho) in shape but was okay (tho it did cramp it bit more, which leads me to...)
personally I never felt right using a Playstation controller...like my *human* hands weren't the target design
(also they haven't changed it [much] so problem not remedied)
mouse and keyboard are definitely good for gaming when you want a gazillion hot keys, and admittedly it took me a long time to move from mouse point and click to using the right analog sticks (I grew up playing with Nintendo controllers, my right thumb was only trained to push buttons haha), but honestly when things got hectic it was just uncomfortable slapping the mouse around, and I'd trade its accuracy for local console co-op fun
(but all in all that's just me, and I can't blame people who hate the 360 controller for its uh...size. wait no yes I can, it's not that big. the original Xbox controller...wow bleh, and Dreamcast)
the Wii...well the ladies seem to like it so...I guess I...liek it? asdjaldkfjd