Destroy was the only option I ever considered. I picked Synthesis once, at the end of my Insanity run, just to see the full cut scene on tv, rather than YouTube. And I loved how shooting that smug little shit Catalyst in the face will automatically trigger the Refusal Ending
Having listened to whatever the Catalyst is, both in the standard and Extended Cut scenes, explain the cold, flawed, overly analytical logic the Reapers used as their motivation for culling the galaxy, they had to burn. Every last single one of them. It was justice, and the only logical thing a emotional human could do. In both Control and Synthesis, they all survived, inspite of the trillions of lives they destroyed over the millenia. I simply felt there was no possible way my Shepard could face his friends, loved ones, comrades, or the rest of the galaxy if the war ended in a draw that left the Reapers alive. How could any of us look into the eyes of a survivor of Thessia, Palavin, Earth or any other world decimated if we didn't destroy them? Extended Cut outcomes aside, whatever the Reapers provide the survivors won't include the people they lost. Simple as that. While the Destroy option may be simpled minded in its Eye for an Eye stance, I couldn't have my Shep pick anything else. And yes, Destroy does give you the Shepard Lives scene at the end, so I'm hoping for a big happy reunion on Earth when the Normandy gets home... Besides, if Shepard lives through Destroy, whose to say he doesnt warn the galaxy about the perpetual war between organics and synthetics? Dead men tell no tales, and Shep ain't dead. Destroy could theoretically be a viable ending in that Shepard's warning prevents another war with sythetics that Synthesis is designed to prevent.
If possible I would like to ask a general question. Knowing what the endings were going to be prior to the Extended Cut, did anyone select a different ending when the choice arose? I ask because I had a weird moment during my fourth playthrough. By that point, the facial recognition issue was finally repaired, so my true Rowan Shepard was finally in ME3, rather than his three previous dopplegangers. Knowing what was in store at the end, I had to properly consider what Rowan would've done in the end had I not known what the choices were going to be. While I did select Destroy again, a lot of thought went into that choice. Did anyone else have an experience like that?