I do like the more tactical side of potions. The "Use this potion to avoid hella damage".
But I don't really like potion crafting / alchemy. It's a lot of boring repetitive gathering and crafting. There needs to be more fun involved. Like if there were poisonous plants or plants that tried to eat you, or a full alchemy lab minigame where you have to carefully mix those highly explosive ingredients or they'll blow up and you'll lose about 1/4 of your health. Only add a twist, in order to gain "Explosion Mastery" you have to blow up your lab a lot, or to gain "Toxicity Mastery" you have to get poisoned a lot. That would make for much more interesting gameplay then it is currently.