Yup, I usually play through at least twice- once as male and once as female. That way I can find a character that sits right with me and with the other characters, story, etc. A few games I specifically prefer a female, for whatever reason- plus, we don't see enough women saving the country/planet/galaxy. Women kicking ass are awesome.
The only games I've played where I couldn't play all the way through as a woman were Skyrim and Dragon Age 2 (the second one, not for the reason most people will assume.) Skyrim I was really bothered by the armour design for female characters- and let's face it, how they look is really the only reason to decide gender for Skyrim, the Dragonborn is hardly a fleshed out character- and in Dragon Age 2, a female Hawke had so many things which just bugged the shit out of me. I'm able to enjoy the game despite it's flaws, but it took me one conversation with a female Hawke for me to decide I hated her voice and the way she ran and the appearance options and just... Argh. Couldn't get past the intro bit with her.
The only games I've played where I couldn't play all the way through as a woman were Skyrim and Dragon Age 2 (the second one, not for the reason most people will assume.) Skyrim I was really bothered by the armour design for female characters- and let's face it, how they look is really the only reason to decide gender for Skyrim, the Dragonborn is hardly a fleshed out character- and in Dragon Age 2, a female Hawke had so many things which just bugged the shit out of me. I'm able to enjoy the game despite it's flaws, but it took me one conversation with a female Hawke for me to decide I hated her voice and the way she ran and the appearance options and just... Argh. Couldn't get past the intro bit with her.