I liked the game and watch the show but I never picked up the comic. So I guess I cast my votes in that order (Game > Show > Never read the comic).
There's one thing I've always particularly disliked about the specifics of the zombie apocalypse scenario that the show follows (I call it the Romero Apocalypse, since it closely follows the way zombies work in his movies). Specifically, it's when any and all people who died from anything other than massive brain trauma injury are guarantied to rise up and become zombies while the survivors ALSO have to deal with their bites being infectious and turning you into zombies. It's just... so bloody unfair. You can never hope to ever win because there's no way to fully quarantine yourself from that. In a sufficiently large group, you're bound to end up with someone who dies from an illness, has a heart attack, committed suicide and so on and everyone he bites, even if it was just a grazing nibble, become zombies as well. There's no way to fight it, short of immediately amputating the bitten limb, when applicable.
The way the show explains it (at least when they were at the CDC), the zombie apocalypse was caused by a virus that's transmitted by bite and attacks the brain, shutting it down. Later, after the person is deceased, the virus kickstarts the brain-stem and you turn into a shuffling torso that likes to nibble on things. Then we're supposed to accept that everyone's infected, yet the virus only attacks and kills your brain if you're bitten. Inconsistency much?
I can get behind a zombie outbreak where it's either/or. Either it's a form of an infection (rage virus, fungus spores, etc) OR the dead are literally walking the earth (caused by funky space radiation, weird ass chemical that reanimates dead, no more room in hell or whatnot) and anyone that dies, no matter the situation will turn. In the latter, a bite wound wouldn't have to be a guarantied death sentence unless of course the bite(s) was(were) severe enough to kill.
At any rate, that's just my rant of frustration. Take it for what it's worth.