I use the Razer DeathAdder (image below). It's not got the massive number of buttons that the MMO mice typically come with, and it's wired, but these were things I was looking for. My previous mouse was ergonomically comfortable, but had very dodgy wireless connectivity, so I was wanted something just as comfortable, but more reliable. It works - I've never had any hand or wrist strain, despite many hours of playing.
<spoiler=Razer DeathAdder> <img width=300> http://www.productwiki.com/upload/images/razer_deathadder_1.jpg
I also own a Razer Goliathus Alpha mousepad, which gives me a massive space over which to play, as well as being ridiculously smooth and comfortable.
My keyboard is a Razer Arctosa - not as fancy as some, but wired so no more signal drops and it can handle the required multiple key-presses at once.