Manly male man here who played the trilogy as FemShep. I once wrote a column for a now-defunct gaming site explaining why I would play as a female character based on a conversation I had with my girlfriend who asked me why I was playing as a woman, prompting me to reply, "Because I want to admire my sexy butt when I have to look at it for the next 30 hours." (To all the snowflakes triggering right now: Toughen up, buttercups. YOU are the only person victimizing you.)
I started playing as female models waaaaaay back in the 20th Century with Quake II MP because I'd turned off the red screen effect when you're shot and relied on the pain grunt to cue me as to when I was taking damage. In a room full of grunting males making the same bro noises, being the girl stood out. I just stuck with it ever since and any game which gives me the option of a female character (that also fits my play style, so Borderlands was an exception) I go with that. Oblivion, Fallout 3/NV, KOTOR, Mass Effect, Dragon Age: Origins, etc. - if there's a femme option, sold. Grand Theft Auto VI needs a female gangster lead. (Tomb Raider and Mirror's Edge took care of business for me.)
Sorry if I don't have a sufficiently SJW-worthy political agenda motivating this preference, it's just my preference. I don't game to indulge in the "male power fantasy" that the harridans who are seeking to ruin gaming and make life generally miserable for all with their cheap Kafkatrapping tactics try to claim. I game to have FUN. Besides, if I wanted to see a ridiculous caricature of stereotypically masculine dudeness, I'll just go look in a mirror.