I chose "other". My favorite villian in Spider-man is J. Jonah Jameson. He's so funny in some of his incarnations. I really liked him in the Spider-man movies too. The best part about him, is that Peter Parker is powerless to do anything about him, yet he pretty much rules and sometimes ruins Peter's life. Peter tries and tries to get a regular job at the paper or at least decent prices for his photos, but the tyrant Jameson won't give it to him.
At the same time, Jameson is also Spider-man's worst enemy in that he can turn the opinion of a large portion of the public against Spider-man and there isn't much Spidey can do about it without looking like more of a villian. Any time Spidey is tempted to take Jameson out, he realizes that by doing so, he then becomes a bad guy himself.
That makes Jameson, one of the few main characters in the Spider-man universe without any super powers, the worst villian of all. Spidey can beat up, knock senseless, tie up and end the schemes of the other bad guys and be justified in it, but he can't do anything much about Jameson.