I can read/watch/play just about anything, but usually I lean heavily towards High Fantasy/Medieval Fantasy. Fairies, Dragons, Toads, Dwarves, Gnomes, Orcs, Trolls, Giants, Wizards, Elves, no real 'technology' as we know it today in the modern world. No space travel, only certain 'guns', no lasers,... MAAAAGIC! You can understand that I had a huge metaphorical boner after the first time I read, 'The Hobbit'. I think the Mass Effect series was one of my only real 'Sci-Fi' space series that I enjoyed.
And the Husband leans heavily in the opposite direction with Sci-Fi. He'll play Sci-Fi Fantasy games, but mostly he prefers things like Eve Online. He's more of a fan of Star Trek than Star Wars, and I prefer Star Wars over Star Trek; here's why, 'The Force'. The concept of the Force is just too magicky for him. I'd try to explain it further, but I know I may not do it as well as he does. However, I think the only real 'Fantasy' games he seems to like to play a lot of are from the Elder Scrolls series. Everything else, he just can't seem to get through as well.