I can't say, I haven't tried it.
Can't beat a boss? Go kill some dudes.
Killing dudes too slow? Kill them harder.
Still too slow? Kill some special dudes for having some nifty items and take them.
Death, a base mechanic of life, is much more prevalent than the larger and more complicated struggle for life.
The problem lies in two parts:
Why it exists? Because it is easy, death is the easiest way to convey victory. Deaths of your enemies that stand in your way allow you to progress through the game at a satisfactory speed. Your death is nowadays not even a game over, but a matter of losing some minutes of progress and random drops if any. And the LATTER part we do complain about.
How do we replace a mechanic like that? You can't. Certain very popular genres - FPS, Hack and Slash, aRPG, Action, TPS - are all based on death mechanics, It might not be a literal death, a graphic death, but a variable in a code reaches a certain point and it is destroyed, the code dies. In bad games it does not even get to pass any code that would survive it, in mediocre games their legacy shall be an increased variable and a footnote detailing his class and death... I got way off track, **** **, i'm not deleting or redoing it. Deal with it.
The death of the player... could be lot of things, but what it boils down to is a loss of progress and time. The existence of NPCs is to provide an obstacle of whatever kind, their reason of being is to hinder the player from progressing. Death is just a common representation of it which forces players to fight against it. A game that provides a single solution *coufpsgh* is a bad game.