Hitman Absolution-Looks like the team has revamped the A.I, introduced more deep stealth and gunplay mechanics, and created a very good graphics engine to boot. My most anticipated by far, I adore Hitman.
Borderlands 2-Borderlands is one of the few games that goes out of its way to create great co-op without phoning it in. More guns, more enemies, better A.I and bigger enviroments will surely cause me to sink hundreds of hours in this one.
Assassin's Creed 3-Hopefully with some revamped gameplay mechanics, it will break the stagnation of the past 2 games.
Dishonored-Steampunk Mirror's Edge/Assassins Creed hybrid. Enough said.