I'm a male and my two best friends are female (one is my wife). My non-wife friend and I have known each other since highschool, we went to university together, and we worked together for a few years. What that resulted in is that there is no line between us anymore, there is very little that we don't know about each other, and very little we could say or do that could offend on another. She's also the reason that I met my wife, in a kind of roundabout way. Way back in university I asked this girl on a date and she assumed that, as I was always with my best friend, that I was dating her and that I was now trying to cheat on her. The girl then told me off and ran to tell my best friend what had transpired. After she realized her mistake she bought me dinner to apologize and we hit it off and now we are married with two kids. Aside from those two, however, all my other close friends are male.
I never found it weird that I had female friends and, other than that one time I just mentioned, I have never had anyone assume that my friend and I are a couple, but that is probably mostly because we live in such a small town that everyone knows everyone and they know that we're just friends.
I never found it weird that I had female friends and, other than that one time I just mentioned, I have never had anyone assume that my friend and I are a couple, but that is probably mostly because we live in such a small town that everyone knows everyone and they know that we're just friends.