Well, Firefox is my all-time favorite all-round webbrowser, but I seem to catch myself using GChrome more and more... still, the only drawback of Firefox is that it gets quite heavy on the system memory usage. Chrome isn't perfect either since it has less add-ons than Firefox and is less customizable and sucks at opening, handling and navigating through more than 50 tabs (I suffer from HMTWBS ? a syndrome I originally invented by myself that means "Hyper Multi-Tab WebBrowsing Syndrome" and so using less than 40 tabs at once is not an option with me).
Anyway, I've tried over 15 different browsers, but the top 3 are always the same in terms of overall functionality and ease of use (my top 3 list):
1. Firefox, still the new overall queen of webbrowsers.
2. Chrome, that little bast*ard's quite fast and its design minimalism is cool, but it still has a long way to go to take the 1st place.
3. Opera, for being the innovator type of browser that all other browser inevitably have to copy from. Still, it lacks Firefox's extensibility in terms of add-ons and that's why it takes the 3rd place in the chart.
There are also other good browsers but they are not as great as the top 3 (for now, who knows, a new Chrome/Firefox/Opera-like one may very well hit the market in the future).