I'm torn between Dragon Quest 10 and Final Fantasy 15. With my limited experience of the DQ franchise, if I've missed it all this time, it's because I'm not patient when it comes to new releases of things that matter. And since the last one took five years to release after it's predecessor, I'm hoping they can get this next one done soon enough.
As for FF15, history tells me this will be the one to shut up the nay-sayers who made up their own genre and finally prove once and for all that Square Enix are capable of learning from their mistakes. Final Fantasy 3 was the first instalment to be better than average, and it followed up a game where just talking to someone slowed the progression down dramatically. And, of course, there was number 9, which followed on from no. 8 which had not just the most idiotic characters ever devised, but a borderline broken battle system to boot. 2, 8 and 13 were all atrocious in their own ways, and they learned from their mistakes each time. I know it's a different team making them now, but a different team made 12 and that turned out okay as far as I can tell.