Id say RPG.
My first choice would be your typical fantasy setting similar to when Forgotten Realms wasnt shat on, obvious this coming from my love of the Baldur's Gate games. However, I cant really see myself explaining any way that it would be unique here, so I wont bother with that.
My other choice would be a Star Trek: The Next Generation sort of RPG styled game. Much of it would try and stay as close to the series format as possible (but not just constant copying episodes, that would be silly). I realise the idea is ridiculous, but just occasional daydreams of mine I think about playing a game where you are both a member of the crew, and able to play as the key characters as well, basically giving the player control and interaction over the ship by controlling or playing a part of it through a variety of different roles. Selecting Picard would give you the decision making role in dealing with problems for example, while playing as Data, or perhaps your own character made to interact with the crew would be more about finding the different solutions to a problem.
I know its an insane and stupid idea for a game obviously created by my blatant fanboy fantasising, but its just an idea that occurred to me because of a bit of careless daydreaming from time to time. Experiencing The Next Generation in new stories on a whole new interactive level couldnt possibly not appeal to me.