Oops. The two negatives in the poll question got me mixed up. I voted Mass Effect 3, and am very upset with myself. My vote should be for MW3 or Saint's Row 3.
EDIT: Forgot to give my reasoning.
Haven't really had an enjoyable time with a Call of Duty game since CoD4, and the Saint's Row games just never really appealed to me. And when one of a game's main selling points seems to be a "sex appeal" slider and a 3 foot purple dildo, I tend to avoid it...
EDIT2: Wanted to comment on the others.
I can't remember the last time I was so excited for a game than I am for Mass Effect 3. The Mass Effect serious just panders to all my interests so well, and I can't wait to finish the series.
Assassin's Creed: Revelations is another game that greatly excites me. I've played and loved every game in the series so far (especially, and apparently unpopularly, the first one), and the amazingly epic cinematic trailer with Iron playing has only fed the fire for me.
I'm not in any rush to get Skyrim, but I'm sure once there's a price drop or inevitable Game of the Year edition, I'll pick it up on the PC.
Finally, I've never been much of an MMORPG player, but SW:TOR looks interesting. If there's a free trial I might give it a shot and then pass judgement, but for now I'm just happy to read the details of the game.