I enjoy the Mass Effect universe too much to give up on it... despite some of the enormous plot holes and lore inconsistencies that ME2 contained. I'll get the third installment eventually, but for now I'm avoiding an installation of Origin. If I find a workaround that lets me buy and play ME3 without Origin, I'll do that. Beyond 3, well, unless they completely ruin the universe with it (and I'm fairly confident they won't)... I'm still game for more Mass Effect.
To be fair, I felt the same way about Valve and Steam when I bought Portal (never been a fan of Half-Life, just Portal). That game sat unplayed on a shelf for a few months before I had researched Steam sufficiently to trust it on my system. So I may just start using Origin eventually. For now, though, I don't trust EA as far as I can throw their headquarters building.