I guess it would come too close to the Ghost in the Shell anime to avoid any calls of plagarism, there's nothing wrong with a female protagonist but a carbon copy of Jensen's personality in female form may feel a little to similar with Maj. Kusanagi in that series.
Both cyborgs, both reserved, both in their 30s, both with issues connecting or identifying with the rest of humanity...blah,blah,blah etc.
The main difference I suppose to OP's idea is that the creator of the series had little interest in drawing anything other than petite women in their early 20s as main characters. So a 30-40 year old female's brain inhabits a mechanical shell of the form of a 20 year old - whereas I never saw anything like that level of tech in Deus Ex.
Anyone else see the similarities between Deus Ex HR and GitS?
I always found it odd that those two cops in the precinct talked about every other movie in the genre EXCEPT this one.