During my first playthrough, I was about to do a Brotherhood mission, but I was tired of the clothes my character (incidentally, an anorectic Asian woman) was wearing, so I decided to come up with a new style first. Don't ask me how, but she ended up wearing a rusty, old Soldier Helmet - and nothing else.
Mission time. To my surprise, the mission I had selected did not involve gunning down legions of gangsters as I had expected. Instead, the goal was to infiltrate the nuclear power plant and steal some radioactive waste.
Yeah.
Cue butt-naked Asian ***** with the physique of a stick figure, grabbing a canister of glowy green stuff and being chased around the power plant by a small army of guys in full hazmat gear with alarms going off all over the place. I laughed so hard I almost failed the mission. (The highlight, I must say, was the helmet. It couldn't be argued that she WASN'T wearing protective gear!)
Another great one was when I was chasing down Ronin leader Shogo Akuji (the young one) who was trying to escape me on his motorcycle. I had grabbed a bike of my own and was sending a massive barrage of SMG bullets in his general direction. One thing I've never been good at in these games, is driving AND aiming at the same time, so whenever two or three bullets out of fifty actually hit the douchebag, I'd consider it a personal triumph.
Eventually, however, I got lucky: Shogo went down a straight road, allowing me to keep him in the reticle long enough to unload at least a WHOLE DAMN MAGAZINE into his bike - enough to make it catch fire!
My ability to hit the guy himself was still normal, though. He was still very much alive and just as eager to escape, so I focused on shooting his bike some more. I was hoping to make it explode before he could get off it, as the explosion would then certainly kill him.
Within seconds, the bike went kablooie, but Shogo's map marker was still on the minimap. He had survived. I ran over to the wreck, but the guy was nowhere to be seen. Even though, according to the map, I was standing right on his marker.
Then I noticed something even stranger: The marker indicated that Shogo was ABOVE me. This was impossible - I was standing on an open street! There was NOTHING there that he could have climbed. He could not have aquired a helicopter on such short notice. I would certainly have heard it. And there are no jetpacks in the game.
I stood there, trying to think of a possible explaination to this deepest of mysteries, until I found my thought processes most rudely and inconveniently interrupted: Something had fallen out of the sky and knocked me over.
It was Shogo Akuji. He was on fire. The fall finished him off. The next thing I saw, was the end-of-mission cutscene.