Alpha Protocol 2. If they just work out all of the bugs, fix some of the gameplay mechanics and make the graphics a bit better, it would be fantastic. But noooo, says Sega, it didn't sell enough to warrant a sequel. Psh. What is the game industry all about these days, profit?!
Not bloody likely!
Oh, and a sequel to Hitman: Blood Money. A great franchise, hopefully IO Interactive can stop pissing around with Kane & Lynch and get back to good ol' fashioned bald assassins. Failing that, they can give the old Freedom Fighters series a jumpstart. Anyone else remember how awesome that game was?