A third installment in the Legaia series. (never gonna happen)
A third installment in the Chrono series - and no, I don't count 'Radical Dreamers' as a Chrono game. (might happen, though I hope it's on a home console and not a a handheld like The Third Birthday)
Jak IV, none of that 'Frontier' stuff on the PSP. I want a fully fleshed out console game from Naughty Dog on the PS3. There are just way too many plot holes that need to be filled, dammit. (Personally, I don't know the odds on this one...)
TimeSplitter IV, because I want 150+ characters, a map maker, 13 different multiplayer modes, 40+ weapons with a wide variety, music by Graeme Norgate, a funny storyline, an arcade mode, challenges, different eras to wreck havoc in and monkeys! (and the odds of that happening seem brighter every day)
Shin Megami Tensei IV, I like Digital Devil Saga and Persona just as much as the next guy, but Shin Megami Tensei III: Nocturne (or Lucifer's Call) is still the best one in my book. So I hope they do another one like it in the main series, instead of all those spin-offs... (this could happen, but the time between SMT II en SMT III was 10 years, so who knows how long it will take this time around?)