Show Me Your Journo-Face
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You're confusing to things. As far as I know, Shh (sonic hedgehog) is not the same as the P53 gene. It is it's official name however, so you were right in that.Mournblade94 said:
It was named that way because the fly (or mice..?) that had a mutation in that gene looked spikey.
http://www.ncbi.nlm.nih.gov/gene/20423
http://www.ncbi.nlm.nih.gov/gene/2768677
http://en.wikipedia.org/wiki/Shh
You would too, if you spent any amount of time around them. Ever check out the SonicRetro forums? People argue about the most pedantic little things, speak with AUTHORITY on subjective matters as though their word were final, even when the rest of the community is doing the exact same thing with a disagreeing stance... It can be a really unpleasant part of the internet.anthony87 said:
That being said, they really do know how to tear apart a Sonic game, find exactly what's wrong with it, and hack it until it's awesome. I'd call them diverse, even EXTREMELY intelligent (well, many of them, at least)... just not particularly sophisticated as a whole.
P.S. Thanks
The name of the gene is not sonic the hedgehog but I did not think it necessary to get that technical here. The protein was indeed named for sonic the Hedgehog. The protein itself unmutated resembles a hedgehog. This particular one was named sonic. All of the proteins in the hedgehog series have the spikey appearance.Thedutchjelle said:
I am correct on all counts. And I better be since I work in the field.
I didn't check your wikipedia link before. Within that reference you provided it will also describe how Shh got its name.
Not sure where you drew the fruit fly conclusion from, but there are many proteins when mutated that take on a 'spiky' form. Shh is spikey in its normal form it is not a mutation.
Not sure where you drew the fruit fly conclusion from, but there are many proteins when mutated that take on a 'spiky' form. Shh is spikey in its normal form it is not a mutation.
Hm. Didnt think of the protein. Kinda weird that P53 doesnt code for the P53 protein..? Normally it works that way, atleast it does for P51. Uniprot tells me SHH codes for the SHH protein, not p53 ( http://www.uniprot.org/uniprot/?query=SHH&sort=score )Mournblade94 said:
So I still don't fully agree. But I'm only a 2nd year student Biomedical Sciences, not a professional, so I could've made a mistake or perhaps simply misunderstood you . I'll stop this here before it gets horrible derailed.
Cheers.
I couldn't hold the laugh myself, being a heart broken sonic fan and all, I still see this as one of the best CM to date. Stay classy, guyz.
Yes it appears my original post of writing off the cuff and not being technical confused youThedutchjelle said:Hm. Didnt think of the protein. Kinda weird that P53 doesnt code for the P53 protein..? Normally it works that way, atleast it does for P51. Uniprot tells me SHH codes for the SHH protein, not p53 ( http://www.uniprot.org/uniprot/?query=SHH&sort=score )Mournblade94 said:
So I still don't fully agree. But I'm only a 2nd year student Biomedical Sciences, not a professional, so I could've made a mistake or perhaps simply misunderstood you . I'll stop this here before it gets horrible derailed.
Cheers.
That was my fault.there is far to many exceptions for any professional or student to keep track of.
p53 makes several proteins. Shh is just one of the many. it depends on the intron splicing. If you are a biomedical student you are going to know p53 very very well.
I'm not trying to be needlessly inflammatory or anything because I love this website, but. . . have you spent any time on the forums here at The Escapist? The average Game Discussion or Off-Topic thread is usually full of people pedantically arguing about how objectively terrible CoD or Battlefield or Gears of War or Halo or Metal Gear Solid or Final Fantasy or Sonic the Hedgehog or Dead Space or Bioshock or WoW or Batman must be because they personally don't like those games. Or how the entire Mass Effect series is ruined forever because of ten minutes of bad writing after 20-30 hours of excellent writing before it, as well as two great games even further before it.Covarr said:
And heavens forbid you ever bring up George Lucas or the Star Wars brand. This is one of the few websites I've ever seen that will start a thread to bash George Lucas and eventually will devolve into a flame war about how the physics of Star Wars work. It's the one website I've been to that will simultaneously bro-fist you for beating Ornstein and Smough and then have the next comment be insulting you for being a mega-geek or something to be able to get past them. Ooh, or more likely from what I've seen, insulting you for thinking those bosses were hard because they had such an easy time with the fight.
Honestly, any fan-base of any game ever made is likely to be crazy when taken as a whole. Sonic might be particularly so, but it's not specific to them. Just look at what happened with Portal, or what's been happening with Half-Life over the last five years, or World of Warcraft, or Mass Effect, or Silent Hill (who, by this point, should be almost as disappointingly dejected as the Sonic fans), or Metal Gear Solid, or Crysis, or Final Fantasy, or do I need to go on?
EDIT: OT: Pretty funny comic, can't help but feel the interviewee would know the journalist thought he was full of it though. I certainly would at least think the man was crazy if he got a face like that.
Tharwen said:That's not a baby seal, it's a furry baguette with a face.RJ 17 said:
Baby seal approves of today's comic and the joke of sophisticated Sonic fans.
He also wants to know how Sonic fans are even still around. >.>
Obviously.
Baby seal will SMITE the non-believers!!!
......after nap time. >.>