One time while climbing a mountain, I got bum rushed by 3 snow bears. "Well, I'm fucked" I thought, but instead of reloading, I decided to give my usual cure-all, Unrelenting Force, a shot. I charged it up all the way and managed to hit all 3 bears, sending them ragdolling down a slope to their deaths.
I also had a dargon related one: I had been ambushed by a dargon and had arrow'd it down to about 1/4 health. It flew away and landed in a near a river. While I was chasing it down, I noticed it firing off breath attacks and its health steadily going down. I got to the site just in time to see a family of mudcrabs finish pinching it to death.