God of War 3
I wasn't looking forward to GTA Chinatown Warsto begin with (after seeing the travesty that was made of Burnout and RE on the DS) but I'm really looking forward to it now that I see that they're trying to make a DS game rather than a severely hamstringed ps2 game. But since that is less than a week from release, I'll revise my answer ahead of time.
I guess the most highly anticipated title for me is God of War 3. I wasn't even really looking forward to that either until I saw the trailer and found out about the crazy levels and battles we're going to play. I don't even care how many quick time events curse the programming, that game looks damn cool.