Adept Mechanicus said:
Honorable mention goes to the Suicide Squigs as they appear in Space Marine. When there's a massive horde of Orks charging at you (and there's never a moment when they're not) they become nigh-impossible to see under all the Boyz. Gameplay becomes pretty much trial and error whenever they show up.
They made for hilarity in multiplayer co-op, though. I had some friends who always played as fragile assault marines, and I always played as devastator with explosive resistance perks. For those of you who haven't played Space Marine, this essentially meant that their entire armour bar and a chunk of their health would be gone to one squig, whereas it took three or four of them to even get through my armour, let alone pose a threat to my health. My teammates' tears were delicious.
Sable Gear said:
And Jockeys fro L4D2. Nuff said.
Every single time I see a jockey, I either turn and run like a little girl back to the safety of the group or instantly focus all my attention on it, hoping to kill the ************ before he can get close enough to jump on me.
But he always gets close enough. Always. And it doesn't matter if the jockey has twelve health, or if you've shot him eight times in the face with an AK-47, or even if your teammates have your back, because he WILL hop on your back and he WILL drag you off to the rape corner where he and a thousand common infected will do horrible, horrible things to you.
OT:
The Mask of Infamy, from The Binding of Isaac.
Oh my holy Christ, words do not describe how infuriating this fucking boss is. Just,
eeeueuuguhghghhh.
Random pathing which often defies its own rules in order to hit you? Check.
Faster than you or your shots? Check.
Can only be hit from one side, and said side is nigh-im
Combines the two worst enemy types in the game? Check.possible to hit? Check.
Obnoxious amounts of health? Check.
No health bar because fuck you? Check.