dunno about brutal agony, but I'm pretty pi$$ed off that I can't access Tenpenny Tower in Fallout 3 anymore.
During the course of the game, plus all of the DLC's, I saved all my spare loot there. All my clothing, weapons, bottlecaps, spare crap and my 20 collected bobble heads were saved in the Tenpenny Tower apartment. Oh yeah, also the 20 Nuka cola quantums I was saving for some quest...
Unfortunately, now I can't get there myself. Every time I try, the game freezes and I have to reboot. There are threads on the internet about this problem, but the solution doesn't work for me.
There's no way I'm starting that game again, if I want to play it further, I just have to grin and bear it.