The weapon you couldn't do without

[Hallow'sEve]

the Sword of a Thousand Truths

 

[MercenaryCanary]

Shiskobab (I think I misspelled it) from Fallout 3.
I had tons of bullets, but I never really did prefer them. So, I went with this.
Silent, Deadly, Efficient, and if the first hit doesn't kill them, the fire usually does.
Also, I find it much more satisfying to sneak up to them, then attack them, with a sickening crack.

 

[Drake the Dragonheart]

I really love my 8-ball launcher from Unreal and Unreal tournament. Rockets and grenades-up to 6 at once-FUN!
I really love the lightning gun from Unreal Championship. Unlike alot of other snipers it is not godly overpowered, though headshot is still instakill, and it retains its usefullness if the target gets in close.

 

[DarthHK]

The old fashioned assault rifle or bolt action rifle (scoped or not).

But NPC's should fear my tilde key, not my weapon.

 

[pha kin su pah]

Sniper Rifle from Halo (lol no scopes)and Lancer from Gears.

 

[Calax]

the Sword of a Thousand Truths

Look up "the Slayer of the Lifeless" and then remember that episode.

Anyway, I'm usually seen zipping around with a SMG (usually a Thompson or a MP5) but I can be convinced to yank out a rifle from time to time (usually in left 4 dead)

 

[Hunde Des Krieg]

Any kind of sniper rifle

 

[roei115]

The uber strong sword that you get at the end of every game but you don't really need it

 

[Chickenlittle]

Assault Rifle from Mass Effect or M6D from Halo: CE. Either wins all.

 

[Church256]

the scorpion in cod4, kicked so much ass and it was double awesome because everyone else hated it

Best SMG in CoD4. So accurate too. I remember all those times switching from my assualt rifle to the scorpion for all those pesky snipers.

 

[new_age_reject]

Quick save/load.

The most powerful of weapons ever.

This
Or the shock/wrench combo in Bioshock.
Or the good ol' Ripper in Fallout3.

 

[Haberley]

Double Enforcers in Unreal Tournament (the original) - was always the only person to use 'em, and my mates hated me cos I could still beat them with their fancy schmancy rocket launchers

 

[Placentipede]

My beautiful BEAUTIFUL!!! MP5 in CoD4 definitely

If its an offline game such as HL2 then I'll only EVER use my pistol

 

[ChaosTheory3133]

.44 Magnum In Fallout 3... close second is the Lincoln repeater, What can I say, I'm a sucker for classic guns.

 

[Uncompetative]

Silenced PP7 in Goldeneye 007:

...obviously, with floaty aiming reticle targeting...

 

[Deschamps]

I'd say the wrench from Bioshock because you could beat the entire game using it and it alone. That was some great game design there.

I kid really, Bioshock was still a very good game, so please don't try to hurt me for saying that Bioshock had flaws.

 

[LadyZephyr]

Shotgun in FPS, tranq gun in third person.

 

[LadyZephyr]

I'd say the wrench from Bioshock because you could beat the entire game using it and it alone.

.... Seriously? :O

 

[Calax]

Double Enforcers in Unreal Tournament (the original) - was always the only person to use 'em, and my mates hated me cos I could still beat them with their fancy schmancy rocket launchers

... Ah UT... I want a redeemer.

For those who don't know a Redeemer was the ultimate weapon, mechanics wise it was a pilot-able rocket that had a MASSIVE explosion. The reason for the explosion story wise (not that there was much of a story) was it was a mini nuke.