The Elder Scrolls is one of the longest running series, featuring some of the biggest, most elaborate, polished and beautiful RPG games ever made. The best thing about Elder Scrolls games is that as much detail and effort is put into making enthralling fantastic environments as is put into weaponry, fighting and shaders. I'm definitely looking forward to Skyrim.
I'm sort of looking forward to Deus Ex 3. The original was top quality, the sequel had it's moments and the third has all the potential in the world. That said, from the videos I've seen of it, it just seems like your typical big-title xbox 360 game of 2011 - all the other consoles will have a needlessly paired down version of the game because xbox 360 can't render top end graphics unless the level scales are tiny.
The levels will never be as expansive or interesting as the original (statue of liberty, and onward) because the frame rate would drop. Such potential being so drastically held back by the weak member of the team... This game should be a PC/PS3 exclusive, or better yet just a PC exclusive. Then we might have beautiful, detailed, but huge environments. Instead we might as well be playing a game that had to be engineered for the Original xbox.
That and there are some other problems; there's no camera bob when you're running etc, i hope they put that in before the final build.
Mass Effect 3 might be good, but i won't spend big bucks on it - I'd wait until it was cheaper. So I probably won't play that for a year or more after it's release.