I'm the minority, Jack and Zaeed are my favorite characters. I lost no one without using a guide. This is why. The game hints at you constantly, particularly through Jacob that you need to upgrade the ship and get loyalty for people to survive, I did all of that, I also took the hint with not diving straight into the Reaper IFF giving me time to, which was lucky or I would have lost the crew. Providing you manage with that, the rest is pretty basic, you need a leader, you can send the same person twice, any leader in the little dossier that pops up when you are asked to pick works, Miranda is an easy choice. Tali is the obvious choice for tech, Samara/Morinth or Jack for Biotics are both are powerful biotic users (I think I used Samara) and as far as the final stand and escort go. Well leave Grunt and some leaders behind like Garrus as they are the most likely to survive, and use someone that isn't highly important to escort the crew, I used Mordin, as I don't like his playstyle, but everyone that isn't a badass with a big gun will do.