Weapon From a Video Game

[Your once and future Fanboy]

this is sort of cheating, but in the Marvel vs Capcom games, Thanos is a playable character:
so my choice is the Infinity Gauntlet.
Omnipotency I chose you!

 

[iLikeHippos]

I'd say the lancer from GoW, but than I might be sued by Cliff E.B...

Maybe that sleeping pistol from MGS 4 that never runs out of ammo. I can think of plenty of opportunities that could come in handy.

 

[GBlair88]

Spoiler: Ganz HMG

Two barreled squad killer that's good for sniping snipers.

Spoiler: GAU-8 Avenger

From quite a few modern war setting games featuring the US. Usually comes with a plane attached and co stars with Tom Hanks in this video.

 

[WolfThomas]

Nanosuit from Crisis. Trust me in my hands, it's a weapon.

I'd of course fight crime with it.

 

[Fetzenfisch]

The best gun ever!

 

[David Stephenson]

either a Gunblade with squalls epic jacket (ffVIII) or Cervantes' Soul Edge with complete pirate outfit both would look so awesome

 

[jonyboy13]

Nevan. An electric guitar that shoots electricity and bats? Yes please.

 

[ShenCS]

The ice skates from Bayonetta. Finally, I kill as pretty as I feel!